Summary of knowledge on hydroxychloroquine

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Summary of knowledge on hydroxychloroquine




by izentrop » 15/12/20, 09:17

The 2 subjects or I could have posted this having been locked, I put it here, it is summarized by an international collective.
HCQ-mort.gif
Mortality (in%) between hydroxychloroquine groups vs control
HCQ-mort.gif (52.75 KiB) Viewed 1489 times

HCQvsControle.gif
Incidence of COVID-19 (in%)
No difference between hydroxychloroquine groups vs control
HCQvsControle.gif (64.25 KiB) Viewed 1489 times

https://public.tableau.com/profile/publ ... /Histoire1
Other topics on the same page:
- Raoult protocol
- c19study other source https://spark.adobe.com/page/lSclwca9VQKis/ who also praise remdesivir https://c19rmd.com/
- The "highly dishonest" Fiolet meta-analysis
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Re: Synthesis of knowledge on hydroxychloroquine




by Christophe » 21/12/20, 13:01

A picture is worth 1000 evils ... Click on the image to have the study reviewed and accepted ...

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Welcome to the world of care bears, son of a bitch.
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Re: Synthesis of knowledge on hydroxychloroquine




by ENERC » 21/12/20, 15:56

The lethal dose is 6 mg per kg (wikipedia)
The molar mass of HCQ is 335 g / mole.
The calculation gives in g: 0.006 / 335 * 1000 * 1000 -> 18 µmoles / kg
At 18 µmoles the patient dies of an overdose. A graph that goes up to 100 is stupid in vivo.

The difference between in vivo and in vitro is that the body eliminates the substance it considers toxic. The concentration in the cells therefore never reaches the fateful threshold of 18 µmoles.
The 2 studies are perfectly consistent: even if there is a reduction in the viral load, it does not prevent the fatal effects of the disease.
If we were 100% around 5 µmoles, yes it would be completely different.
Nothing conspiratorial about it: it's just chemistry. A substance that works 100% in vitro at 1/2 the lethal dose in vivo will be the remedy that works.
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Re: Synthesis of knowledge on hydroxychloroquine




by Christophe » 21/12/20, 16:08

ENERC wrote:The lethal dose is 6 mg per kg (wikipedia)
The molar mass of HCQ is 335 g / mole.
The calculation gives in g: 0.006 / 335 * 1000 * 1000 -> 18 µmoles / kg
At 18 µmoles the patient dies of an overdose. A graph that goes up to 100 is stupid in vivo.


Good verification approach (I trust you on the 6 mG and the 335 g / M)

Except; if I follow you well, your last sentence since you go from 18 µM / kg to 18 µM per individual!

A man of 80 kg can therefore tolerate with a safety factor of 2: 18 * 80/2 = 720 µM !?

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Re: Synthesis of knowledge on hydroxychloroquine




by izentrop » 21/12/20, 17:48

ENERC wrote:The difference between in vivo and in vitro is that the body eliminates the substance it considers toxic. The concentration in the cells therefore never reaches the fateful threshold.
This is a first reason.
Then it was the randomized studies that decided.

The position of the HCSP has not changed since March
there is currently no data to consider the off-protocol use of hydroxychloroquine for Covid-19 prophylaxis.
https://www.hcsp.fr/Explore.cgi/avisrap ... ?clefr=785

Last recommendation of 25/11/2020
With regard to chloroquine and hydroxychloroquine alone or combined with azthromycin, not to prescribe this drug whatever the situation (neither on an outpatient basis, nor in hospitalization, nor as pre-exposure prophylaxis, nor as a cure, nor in post-exposure prophylaxis).
https://www.hcsp.fr/explore.cgi/avisrap ... ?clefr=954
That of the WHO has not changed either.

Summary of What's on my plate updated in December https://quoidansmonassiette.fr/covid-19 ... loroquine/
It is the randomized ones that are authentic.
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Re: Synthesis of knowledge on hydroxychloroquine




by ENERC » 21/12/20, 19:08

Christophe wrote:
ENERC wrote:The lethal dose is 6 mg per kg (wikipedia)
The molar mass of HCQ is 335 g / mole.
The calculation gives in g: 0.006 / 335 * 1000 * 1000 -> 18 µmoles / kg
At 18 µmoles the patient dies of an overdose. A graph that goes up to 100 is stupid in vivo.


Good verification approach (I trust you on the 6 mG and the 335 g / M)

Except; if I follow you well, your last sentence since you go from 18 µM / kg to 18 µM per individual!

A man of 80 kg can therefore tolerate with a safety factor of 2: 18 * 80/2 = 720 µM !?

Do I love myself?

No it's good per kg.
For example for 70 kg, that gives 18 µM * 1000 * 1000 (moles) * 335 (g / mole) -> 422 mg. Or 6 mg / kg, that's also 420mg for 70kg.
If all of the HCQ is evacuated in 24 hours, the maximum dose would be 400 mg / day for a person weighing 70 kg.
With 800 mg per day, either they take the risk of exceeding the limit, or the HCQ is evacuated more quickly.
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Re: Synthesis of knowledge on hydroxychloroquine




by izentrop » 21/12/20, 20:37

ENERC wrote:The lethal dose is 6 mg per kg (wikipedia)
The molar mass of HCQ is 335 g / mole.
Where did you get the LD50?
Here a study on cytoxicity https://www.nature.com/articles/s41421-020-0156-0#Fig1
Image https://www.acsh.org/news/2020/03/25/wi ... -cut-14663
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Re: Synthesis of knowledge on hydroxychloroquine




by Christophe » 21/12/20, 22:56

ENERC wrote:No it's good per kg.
For example for 70 kg, that gives 18 µM * 1000 * 1000 (moles) * 335 (g / mole) -> 422 mg. Or 6 mg / kg, that's also 420mg for 70kg.
If all of the HCQ is evacuated in 24 hours, the maximum dose would be 400 mg / day for a person weighing 70 kg.
With 800 mg per day, either they take the risk of exceeding the limit, or the HCQ is evacuated more quickly.


Yes ok ... but so when the graph speaks of concentration in uM it is therefore implied uM / kg?
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Re: Synthesis of knowledge on hydroxychloroquine




by ABC2019 » 22/12/20, 06:58

Christophe wrote:Yes ok ... but so when the graph speaks of concentration in uM it is therefore implied uM / kg?

M is the abbreviation used for mole / liter, not mole / kg, for dilution in a liquid. The in vitro experiments are not done in "meat" but in cells cultured in solution, so it makes more sense to speak in mole / liter, but to administer the product to a real someone, we will rather speak mole / kg. It is comparable because the density of living matter is close to 1, but one of the essential differences is that when you swallow a pill it will not distribute evenly in your body as in a bottle, there are problems. distribution complexes in the body, transport of the molecule to cells, biological filtration, excretion ... it is also the origin of the differences between effect in vitro and in vivo.

But hey that's the concerns of materialist scientists who believe that it is really the molecules that act and not a "magic" effect, who think that the effect is higher if the concentration is higher as shown by the tests in vitro, who carry out laboratory experiments and statistical tests on animals and people before asserting the effectiveness of a molecule ... in short, narrow-minded people, sectarians and materialists, who know nothing about real life, and which are subject to the interests of BP what.
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Re: Synthesis of knowledge on hydroxychloroquine




by Christophe » 22/12/20, 08:02

Bin thin then ... I did not know this subtlety ... ok by L then ...

What is the exact average density of the human body? : Mrgreen:
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