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Obamot
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Covid-19: vaccines and immunology

Unread Messageby Obamot » 20/07/20, 19:04

Positive clinical trials for three vaccines
Sources (compilation): ATS / The Lancet medical journal / developer sites / 20.7.2020 - 16:49 / 19:04
/ Wikipedia: https://fr.wikipedia.org/wiki/Vaccin_co ... A9clinique

More than 150 vaccine candidates are under development and testing around the world in an attempt to stop the coronavirus pandemic. Twenty-three of them are in clinical trials in humans,
The experts (not the self-proclaimed econology : Mrgreen: ) warned that it will take 12 months to 18 months to develop a safe and effective vaccine. I'm generally against vaccinations, but this time I would probably get vaccinated anyway! 8)

AZD1222 vaccine candidate,
Development: 'Oxford University in partnership with AstraZeneca ”
Trial on more than 1000 patients.
Method: adenovirus *
Adjuvant / s: not specified / s
First result: “strong immune response obtained”.
Treatment deemed “safe”
Side effects: not caused serious side effects.
Preliminary phases: I / II completed.
Phase III - efficacy validation (for mass production): to come.
Availability: end of year (forecast) available in Brazil (trials)
More details:
https://www.astrazeneca.com/media-centr ... trial.html
https://www.ox.ac.uk/news/2020-06-14-as ... -no-profit
https://www.ox.ac.uk/news/2020-06-28-tr ... rts-brazil

Ad5-nCOV vaccine candidate
Development: CanSino Biologics and the “Chinese Military Research Unit”.
Trial on 500 patients.
Method: adenovirus *
Adjuvant / s: not specified / s
First result: “caused a strong reaction in terms of antibodies” in most of the approximately 500 participants.
Treatment deemed “safe”
Preliminary phases: I / II completed. CanSino Biologics has been given the green light for use in the Chinese military.
Phase III - efficacy validation (for mass production): to come.
Availability: available for the military imminently.
More details:
http://www.cansinotech.com/uploads/arti ... Kkhj24.pdf
http://www.cansinotech.com/homes/articl ... 6/153.html
http://www.cansinotech.com/uploads/arti ... m56gF4.pdf (old)

MRNA-1273 vaccine candidate
Development: Moderna, US National Institute of Allergy and Infectious Diseases (NIAID)
Trial on 45 subjects (enrollment phase on 30)
Method: strand of messenger RNA that codes for the glycoprotein (s) which ruffles the outer envelope of SARS-CoV-2 (spike glycoprotein). This messenger RNA is encapsulated in lipid nanoparticles in a “pre-fusion” configuration.
Adjuvant / s: not specified / s
First result:
Treatment
Preliminary phase: phase I
Phase III -
Availability:
More details:
https://www.modernatx.com/modernas-work ... t-covid-19

Vaccine candidate: BNT162 (but 4 vaccine candidates, and they will diffuse the most “safe”)
Development: BioNTech / Pfizer
Essay on: planned 360 “healthy” subjects.
Method: mRNA
Adjuvant / s: not specified / s
First result: “induced an immune response in patients”
Treatment deemed “safe”
Preliminary phase: Phase 1/2
Phase III - validation of efficacy (for mass production):
Availability:
More details:
https://www.pfizer.com/news/press-relea ... nt_program

___________________________

Other andidates-vaccines:

Preclinical research reports
https://fr.wikipedia.org/wiki/Vaccin_co ... A9clinique

CoronaVac vaccine candidate,
Development: Sinovac Biotech / China

Vaccine candidates: ChAdOx1 nCoV-19,
Development: Jenner Institute, University of Oxford,

___________________________


* The virus called “adenovirus” is designed to carry the genetic material of the novel coronavirus protein in the human body.
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Re: Covid-19: list of effective vaccines

Unread Messageby ENERC » 20/07/20, 19:29

Obamot wrote:The experts (not the self-proclaimed econology : Mrgreen: ) warned that it will take 12 months to 18 months to develop a safe and effective vaccine. I'm generally against vaccinations, but this time I would probably get vaccinated anyway!

You already have to know how long the immunity lasts. If she is 4 months old and you have to be vaccinated 3 times a year, well ... in this case the vaccine does not help much.

There is another point of attention: a few people caught up with the Covid some time later and in a more serious way. The cases are being analyzed, but in any case, that raises the question of the reaction during the second vaccination a few months later.

From what I understand, the Moderna vaccine cannot be produced in billions of doses per year, whereas AstraZeneca's could.
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Re: Covid-19: list of effective vaccines

Unread Messageby Obamot » 20/07/20, 19:36

Professor Didier Pittet of the HUG assumes that this covid-19 virus behaving like other viruses, there would be no reason that an organism having been infected by it once, should not recognize it afterwards. .
Otherwise the experts would not believe in “group immunity”

https://www.rts.ch/info/regions/geneve/ ... rance.html

The starting infection rate of 1 for every 3,8 people infected has dropped to just over 1 (ideally below 1.
It is therefore encouraging of a decrease in virulence.

He says it in this video:

- “we can occasionally fall ill again, but we will not fall ill again so"
http://www.lemanbleu.ch/fr/News/Quel-es ... ID-19.html
Last edited by Obamot the 20 / 07 / 20, 19: 47, 1 edited once.
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Re: Covid-19: list of effective vaccines

Unread Messageby phil59 » 20/07/20, 19:45

I admit that I will be careful about a vaccine.

And as I had it, when it did not yet officially exist, well, I have a little time, well, I hope!
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Re: Covid-19: list of effective vaccines

Unread Messageby Obamot » 20/07/20, 19:48

phil59 wrote:I admit that I will be careful about a vaccine.

And as I had it, when it did not yet officially exist, well, I have a little time, well, I hope!


You had covid-19 :?:

If so, you're lucky, you won't need a vaccine. It's better than a vaccine, the cells then recognized the virus coated with its layer of glucose (behind which it is hidden), which not all organisms manage to do ... In this case I would not be vaccinated to avoid causing confusion later (after making sure) ...
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Re: Covid-19: list of effective vaccines

Unread Messageby phil59 » 20/07/20, 20:00

Well, let's say that at the end of 2019, after a stay outside France, in the hotel where I spent 3-4 nights, there was 1 "Chinese" bus.

A few days after coming home, cough, etc ....

A real rag ... Not the strength to wash yourself, and have lunch right after, and even sometimes, you brush your teeth, and you go back to bed immediately, not the strength to engage in the shaving ... Etc .... loss of taste ...

The doctor at the time did not really know what I had, and told me "that it was a thing which turned" ... well, there is extreme possibility that it is that ... .

Normally, I will see the doctor next week, and I will ask him a "serological thing" ....

So if so, luck not to be staying there, because as we didn't know how far it could go, no big worry ... well, I saw him 3 times in a week at the start to tell him that it was not going at all .... and twice the following week ....
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Re: Covid-19: list of effective vaccines

Unread Messageby Obamot » 20/07/20, 20:19

Thanks for the feedback ! Image Yes, you better check if you have typical igGs ...

If not, have you ever had the seasonal flu?
If so, how long does it last?
Severely? Symptoms ? Lots of fever?
How frequently ?
Last edited by Obamot the 20 / 07 / 20, 20: 28, 1 edited once.
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Re: Covid-19: list of effective vaccines

Unread Messageby phil59 » 20/07/20, 20:27

Well, the flu, yes, maybe a day or two in bad shape, but that's it. Rarely needed a stop for this ....
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Re: Covid-19: list of effective vaccines

Unread Messageby Obamot » 20/07/20, 20:29

phil59 wrote:Well, the flu, yes, maybe a day or two in bad shape, but that's it. Rarely needed a stop for this ....

Cold or flu?

Cold and no sinusitis afterwards?
Fever?
Every year? Every two years ... 4 years ..
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Re: Covid-19: list of effective vaccines

Unread Messageby Obamot » 20/07/20, 20:40

Here is a site that lists studies on vaccines (and molecules):

633BB7BC-2A68-4A9A-98FF-BD2A20307A30.jpeg


You just have to click in the list at the top right on: “vaccine”

https://covid-trials.org/
Last edited by Obamot the 20 / 07 / 20, 20: 51, 2 edited once.
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