Respiratory toxicity of diesel particles

Air quality has become a major issue in the environmental policy of industrialized countries.

Indeed, a set of presumptions, based on epidemiological studies carried out over the last twenty years, makes it possible to establish a probable relationship between certain pollutants such as atmospheric particles and mortality or morbidity of respiratory and cardiovascular origin.

However, it is not always easy to establish a clear causal relationship between a given pollutant and a health effect. Diesel particles have been rapidly implicated in the worsening of respiratory diseases such as asthma, as their small size allows them to access the deep lung.

Recent experimental studies have shed light on the molecular mechanisms underlying the inflammatory response induced by these particles. These could go through the production of activated species of oxygen that play
a central role, currently recognized, in many diseases.

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