Covid-19 vaccine: what if we never found it like HIV AIDS?

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Christophe
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Covid-19 vaccine: what if we never found it like HIV AIDS?

by Christophe » 25/04/20, 14:13

The covid19 vaccine is presented as THE absolute solution to stop the pandemic ... heard on the radio this week: Germany is launching its 4th clinical trial of a vaccine. Does this mean that the first 3 failed?

And if we could not find a vaccine for this coronavirus, I am not a virologist but there is at least one precedent in history: HIV ... so the vaccines are like antibiotics: it's not automatic!

Today after almost 40 years of research, we no longer die of AIDS thanks to molecules ... but it took 20 to 25 years to find these solutions ...

Sorry to have rotted you on your Saturday afternoon : Mrgreen: but it is a track that must be considered ...
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by izentrop » 25/04/20, 16:25

"Better to ask the good god than her breasts ... Uh! Saints" said my mother : Mrgreen: ...
There seems to be good hopes
A vaccine model already under development in other indications

“This same approach for the development of new vaccines has already been used by teams at the Institut Pasteur in recent years. The most advanced project today, based on this technology, is a combined measles-Chikungunya vaccine candidate, "said Professor Stewart Cole, Director General of the Institut Pasteur Institut Pasteur. It is a promising vaccine candidate for this chikungunya infection and phase III clinical trials will start in the second half of 2020, also funded by CEPI and piloted by Themis. “This vaccine candidate has already been shown to be well tolerated and immunogenic. The highest doses tested resulted in 90% seroconversion of subjects following a single immunization, indicating that a single dose may be sufficient to achieve clinical effect, which is crucial in an epidemic.

This vaccine model using the measles vaccine as a vector has also shown indicators of interest against the related virus SARS-CoV (now called Sars-CoV-1), but also against MERS-CoV, in a model animal. Other vaccine candidates based on this model are currently in clinical development and target the Zika viruses (funded by the European Union) and Lassa (funded by CEPI). https://www.pasteur.fr/fr/espace-presse ... m-institut
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by ENERC » 25/04/20, 17:34

This article from Vidal is not very optimistic:
Vaccinology against coronaviruses, a fledgling science .....

In conclusion, there is still a long way to go in understanding immunity to CoV, in particular that relating to the production of a lasting immune memory. The lack of flagrant vaccine success with MERS-CoV (and with SARS-CoV-1 until it leaves the researchers' perimeter of interest) is not encouraging, especially since the vaccines currently in use The study seems to focus more on the production of neutralizing antibodies than on the stimulation of cellular, in particular local, immunity. This is despite the lessons learned by studying SARS or MERS, or those from recent research on the immune response to SARS-CoV-2.

https://www.vidal.fr/actualites/24740/v ... ars_cov_2/
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by Christophe » 25/04/20, 23:26

It starts well: 2 contradictory answers ... : Cheesy:

The contradiction is obviously part of the RNA of this coronavirus ... : Cheesy:
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by GuyGadebois » 25/04/20, 23:37

Don't worry Christophe, soon the nanoparticle and messenger RNA * vaccine. Expensive, much more expensive than the Raoult protocol and tested on paid HUMAN guinea pigs. Everything is going well and is brought together for a beautiful future randomized study, double blind and rigged from start to finish as it is nowadays. But ... it will satisfy the followers of the science sect. : Mrgreen:
(Translated)
http://translate.google.com/translate?h ... -19-begins
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by izentrop » 26/04/20, 02:49

ENERC wrote:This article from Vidal is not very optimistic:
Vaccinology against coronaviruses, a fledgling science .....

In conclusion, there is still a long way to go ....

https://www.vidal.fr/actualites/24740/v ... ars_cov_2/
But after the conclusion:
(Edit of April 20, 2020) Researchers from the NIH have just released the results of a trial of the vaccine ChAdOX1 (protein S of MERS-CoV carried by a chimpanzee adenovirus) against MERS. The vaccine was administered to 3 groups of 6 macaques, including a control group. The two protocols chosen were either a single vaccination 28 days before the viral challenge, or a double administration 56 days then 28 days before the viral challenge. The two experimental groups were protected from the appearance of symptoms, with a strong reduction in the pulmonary viral load. In addition, no sign of viral replication was detected in the double-vaccinated group. In vitro, the antibodies obtained neutralize 6 strains of MERS-CoV. No data were published on the possible presence of facilitating antibodies, nor on the reaction to a later viral challenge. A phase 1 trial with this vaccine is currently being conducted in humans in the UK and Saudi Arabia.
Chimpanzees, macaques, ... soon zumans : Mrgreen:
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by Christophe » 26/04/20, 03:06

Someone tells them that the Seas is not covid19? : Lol:
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by Ahmed » 26/04/20, 07:22

This concern with wanting to develop a vaccine confirms (if need be!) Our inclination to want to exonerate ourselves from the consequences in order to better persevere in encouraging causes ... : roll:
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by izentrop » 26/04/20, 08:22

Christophe wrote:Someone tells them that the Seas is not covid19? : Lol:
It's ass and shirt all the same https://fr.wikipedia.org/wiki/Betacoronavirus#Virologie

Ahmed, the law of the strongest is outdated among the civilized. Collective consciousness not based on ideologies can lead to well-being for all, just stop the bullshit.

The middle ages can be a dream when you see the series on Netflix with actors dressed in outfits just out of the dyer. We never see them working, but hey it was a little harder than it seems to survive at that time.
Last edited by izentrop the 26 / 04 / 20, 08: 40, 2 edited once.
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Re: Covid-19 vaccine: what if we never found one like HIV AIDS?

by Macro » 26/04/20, 08:32

Low need for vaccine for the hiv ... It is enough not to exchange its syringes (or more simply to avoid becoming junky) and not to go to dip its biscuit in anyone if you did not thread a latex suit to him ...

But you have to ask the Africans ... they automatically found an alternative thing ... For AIDS it was enough to deflower a virgin ....
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