Heinrich-Heine-University,
Study on ambulatory patients infected with COVID-19Early treatment with reduced risk with zinc plus low dose hydroxychloroquine and azithromycin: retrospective study of a case series SummaryObjective: To describe the outcome of patients with coronavirus disease 2019 (COVID-19) on an outpatient basis after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) based on risk stratification .
Purpose: Retrospective study of case series.
Setting: General medicine.
Participants: 141 COVID-19 patients with laboratory-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in 2020.
Main outcome parameters: Risk-based treatment decision, rate of hospitalization and death from all causes.
Results: Of the 335 COVID-19 patients who tested positive by PCR, 127 were treated with triple therapy. 104 of 127 patients met the defined risk classification criteria and were included in the analysis.
In addition, 37 treated and eligible patients who were confirmed by IgG tests were included in the treatment group (total N = 141). 208 of 335 patients did not meet the criteria for risk classification and were not treated.
After 4 days (median, IQR 3-6, available for N = 66/141) of symptom onset, 141 patients (median age 58 years, IQR 40-67; 73% male) received a prescription for triple therapy for 5 days.
Independent public benchmark data from 377 confirmed COVID-19 patients from the same community was used as a control and not treated.
- 4 of the 141 patients treated (2,8%) were hospitalized, which is significantly less (p <0,001)
compared to
- 58 of 377 untreated patients (15,4%) (odds ratio 0,16, 95% CI 0,06-0,5).
Therefore, the chances of hospitalization for treated patients were 84% lower than in the untreated group.
One patient (0,7%) died in the treated group
VS.
13 patients (3,5%) in the untreated group (odds ratio 0,2, 95% CI 0,03-1,5; p = 0,16).
No cardiac side effects were observed.
Conclusions: Treatment based on the risk classification of COVID-19 outpatients as soon as possible after the onset of symptoms with the triple therapy used, including the combination of zinc and low-dose hydroxychloroquine, has been associated with a significantly lower number of hospitalizations and 5 times fewer deaths from all causes.
Translation of the link given by Guy:
https://www.preprints.org/manuscript/202007.0025/v1