The magic of sdhi, another disaster to come ...

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GuyGadebois
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 18/02/20, 15:59

izentrop wrote:And if you were interested in the message instead of constantly repeating your proselytizing litany. : Evil:

You and Janic, the two preachers of the forum.

Stop the bullshit for two seconds. The proselyte * is you. Me it is the opposite ** and I do not believe a word traitre of all these swellings which work at the same time for organizations supposed to represent us and the industrialists. You do, and it's even the only sources you drink from. So sorry but will therefore revise your dictionary.


* member, affiliated, defender, broadcaster, propagandist, propagator, sympathizer, tenant, zealot.

** adversary, opponent, enemy, layman
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Re: The magic of sdhi, another disaster to come ...




by izentrop » 18/02/20, 23:47

I hope for you that you have the book Image Otherwise it is on sale at Biocoop with a bonus of one kg of Demeter label potatoes. : Mrgreen:
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 19/02/20, 12:27

Since we are on reading tips, I encourage you to urgently get this book that can help you unravel the mysteries of your tortured mind:
Image
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“It is better to mobilize your intelligence on bullshit than to mobilize your bullshit on intelligent things. (J.Rouxel)
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Re: The magic of sdhi, another disaster to come ...




by izentrop » 20/02/20, 12:23

To do with the "prejudice" mode off
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 20/02/20, 12:33

izentrop wrote:To do with the "prejudice" mode off

It was a message from the UIPP (I invent nothing, the video is badged):
The Union of Plant Protection Industries is a French professional organization and lobby grouping together companies that market phytosanitary products, pesticides and more generally any technological solution in favor of crop protection in France. (Wiki)
We can trust them!
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"By definition the cause is the product of the effect". (Tryphion)
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 16/06/20, 13:02

SDHI pesticides: they revive the controversy
After glyphosate and neonicotinoids, the latest agricultural controversy concerns "SDHI fungicides". These pesticides are sprayed on fields and lawns to prevent certain diseases of the plants linked to microscopic fungi. They have been used since the 1960s and their worldwide consumption is growing by around 20% per year. But, at the start of the year, 450 scientists called on the French Health Security Agency (ANSES) to "apply the precautionary principle, contained in the Constitution" and to ban them.
Scientists worry ...

SDHI stands for "succinate dehydrogenase inhibitors". These molecules derive their fungicidal potential from the inhibition of this enzyme, which is essential for the cellular respiration of fungi ...

but also of all plants and animals. And therein lies the rub: as early as 1976, a Californian team demonstrated the capacity of an SDHI to alter the respiration of beef cells, and other experiments have since suggested the harmful effects of certain SDHIs on populations of worms. of earth and insects. Last fall, a French team even suggested the action capacity of several SDHIs on 22 different species and confirmed its toxicity on human cells.
… And challenge health expertise

No health agency in the world has considered these signals sufficiently disturbing to ban these products. In January 2019, a group of four experts assembled by ANSES thus concluded that the scientific data, taken as a whole, did not suggest a health or ecological risk.

"The ANSES study focused on cancer, while the risks are above all neurological", plague Pierre Rustin, specialist in mitochondrial diseases (CNRS). On January 23, in a debate at the Parliamentary Office for the Evaluation of Scientific and Technological Choices, the director of ANSES admitted that he did not have enough means to carry out more in-depth tests ... *

https://www.science-et-vie.com/nature-e ... erse-54223

* The Health Security Agency (ANSES), which had estimated in January that no health alert was immediately justified, stressed Friday "continue its work on potential effects of these substances on health in real exposure conditions "And having" asked Inserm to take into account the data in this publication, as well as other recent publications ".
She estimated in a press release "risky to compare the values ​​(...) obtained in vitro under laboratory conditions with the concentrations of SDHI which could result from the application of pesticides on crops", and indicates also working on "the question cumulative exposures to the various SDHI fungicides via food ”, on which it“ will publish its results in the first half of 2020 ”.
For its part, the UIPP, which represents industrial producers of phytosanitary products, noted that ANSES "has expressed very clearly reassuring opinions on SDHIs three times in the past nine months".
gardening / the-feerie des sdhi-a-different-disaster-has-come-t16117-10.html # p371995

We finally have proof of the lie of ANSES which I was already denouncing.
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Re: The magic of sdhi, another disaster to come ...




by izentrop » 16/06/20, 14:47

Pierre Rustin is like Raoult, alone against the entire scientific community. So imbued with themselves that they don't need rambling studies to be right. http://seppi.over-blog.com/2020/01/fong ... urrie.html
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 16/06/20, 15:49

izentrop wrote:Pierre Rustin <<< Pierre Rustin + 450 scientists it's like Raoult, alone against the whole scientific community. So imbued with themselves that they don't need rambling studies to be right. http://seppi.over-blog.com/2020/01/fong ... urrie.html

And you, whether it is about Raoult or other subjects (GMO, Glyphosate, SDHI) you always rehash the same nonsense ("in vitro not in vivo", randomization blah *), always referring to the worst sources of lies , conflict of interest, collusion, corruption and incompetence. Astonishing, no?

* As if all the poisons marketed had been the subject of randomized studies double-blind blah ...
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“It is better to mobilize your intelligence on bullshit than to mobilize your bullshit on intelligent things. (J.Rouxel)
"By definition the cause is the product of the effect". (Tryphion)
"360 / 000 / 0,5 is 100 million and not 72 million" (AVC)
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GuyGadebois
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Re: The magic of sdhi, another disaster to come ...




by GuyGadebois » 16/06/20, 19:11

And always double blind, don't forget ...
suppositories4.png..jpg
suppositoires4.png..jpg (78.26 KiB) Consulted 4747 times
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“It is better to mobilize your intelligence on bullshit than to mobilize your bullshit on intelligent things. (J.Rouxel)
"By definition the cause is the product of the effect". (Tryphion)
"360 / 000 / 0,5 is 100 million and not 72 million" (AVC)
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Re: The magic of sdhi, another disaster to come ...




by GuyGadeboisTheBack » 18/01/24, 19:09

1- ANSES criticized by ANSES

The credibility of ANSES questioned by its own scientific council


In a report on the National Health Security Agency, independent experts are concerned about the “gap between science and expertise” within the institution and recommend a reform of its functioning.


No press release, no trace on the front page of its website: the report was put online discreetly, Friday March 10, by the National Agency for Food, Environmental and Health Safety. of work (Anses). And for good reason, the 139-page document, which Le Monde consulted, concerns the “credibility of the scientific expertise” carried out by the agency, and its conclusions are not flattering.

Glyphosate, neonicotinoids, SDHI fungicides: in recent years, in several sensitive issues, the opinions issued by the health authority have been at the center of heated controversies. To the point that the ANSES scientific council – made up of around thirty scientists, most of them independent of the agency – deemed it necessary to mandate a working group to analyze the situation and make recommendations. “This situation could, if not managed carefully, threaten the credibility of the agency,” warns the working group, created in the fall of 2020 and led by Pierre-Benoît Joly, president of the Inrae Occitanie-Toulouse center. .

Expertise is at the heart of “three major tensions”, notes the report. The first is “the need to take into account the most advanced scientific knowledge”. “The gap between science and expertise constitutes one of the most important factors in the erosion of credibility and ANSES does not always succeed in reducing this tension,” write the members of the scientific council. Second tension listed: “the urgency of rendering certain opinions”, leading to deviating from the usual rules of expertise to, ultimately, produce “fragile results”.

The third tension identified by the rapporteurs is institutional. Since 2015, ANSES has been responsible not only for assessing the risks linked to certain products (pesticides, biocides, veterinary medicines), but also for their regulation. It regulates their uses, grants or not marketing authorizations or decrees their withdrawal. Before 2015, it was the Directorate General for Food, at the Ministry of Agriculture, which was responsible for this mission. For the rapporteurs, this mixture of genres imposed on the agency contributes to “the erosion of its credibility”.
https://www.lemonde.fr/planete/article/ ... _3244.html
The report: https://www.anses.fr/fr/system/files/AV ... ertise.pdf


2- The long-awaited study update: a rout!
December 5, 2023, CONTROVERSY AT ANSES:
According to this, there is no “unacceptable risk for consumers” provided that 11 of the 39 toxicological reference values ​​(TRV) are adjusted, “by moderately reducing their current value by a reduction factor ranging from 1,5 to 3,3”
But this opinion includes in annex the divergent position of two members of the working group (out of 15 scientists gathered, 3 resigned, four wrote eight divergent opinions and certain observations were relegated to a simple “appendix”) Their criticisms relate to the way in which the expertise was carried out. They particularly deplore that the results of a cross-sectional analysis of the toxic effects of SDHIs were underestimated. “This analysis, innovative compared to the regulatory evaluation substance by substance, aimed to clarify the common or different organ toxicities for all the SDHIs assessed”. Indeed, the analysis revealed “numerous and shared damage between SDHIs for the kidney, endocrine disruption, neurotoxicity, eye diseases, damage to the adrenals, heart, liver, thyroid”. According to them, the minimization of these results "has the consequence of reducing the scope of collective expertise and of centering the results on the purely regulatory question of the analysis of VTRs", whereas it would have been necessary "to have a broader vision of the problem of SDHI” instead of a simple “academic guarantee”.
https://alerte-medecins-pesticides.fr/r ... sier-sdhi/
The bogus ANSES study: https://www.anses.fr/fr/content/nouvell ... aceutiques

3- The first consequences on humans with resistant and deadly mutant fungi:
Solid-state NMR to understand pulmonary aspergillosis
Spores of fungal agents such as Aspergillus fumigatus, inhaled by immunocompromised hosts, can lead to fatal illnesses. In work published in the journal PNAS, scientists from the Institute of Chemistry and Biology of Membranes and Nanoobjects (CNRS/University of Bordeaux/Bordeaux INP) and the European Institute of Chemistry and Biology (CNRS/University of Bordeaux /Inserm), in collaboration with the Pasteur Institute, have developed a new approach using solid-state NMR spectroscopy to characterize, at the atomic scale, the evolution of the cell wall of its spores throughout their growth cycle. life.
https://www.inc.cnrs.fr/fr/cnrsinfo/la- ... pulmonaire

The multifungicide resistance status of Aspergillus fumigatus populations in arable soils and in the wider European environment
This study also shows that in addition to azole resistance, several A. fumigatus lines carrying TR-based CYP51A variants also developed acquired resistance to methyl benzimidazole carbamate, the outer quinone inhibitor and to succinate dehydrogenase (Sdh) inhibitor fungicides through target site alterations. in the corresponding fungicidal target proteins; beta-tubulin (F200Y), cytochrome b (G143A), and Sdh B subunit (H270Y and H270R), respectively.
https://www.google.com/url?sa=t&rct=j&q ... i=89978449

Candida Auris and Aspergillus fumigatus, again:
Mushrooms are resisting
In October 2022, the World Health Organization (WHO) warned of a growing threat: Mushrooms.
The international organization published a list of 19 species to be monitored as a priority and called for an intensification of scientific research on these too often neglected pathogens. “For around ten years, we have seen the emergence of new species, which could be linked to climate change also leading to a modification of the distribution areas of certain known fungi,” explains Sarah Dellière, researcher at the Pasteur Institute and microbiologist. at the Saint-Louis AP-HP hospital. Among these emergences, that of Candida auris is enough to attract attention. This yeast discovered in 2009 is harmless when it colonizes the skin. But when it enters the bloodstream, often following a medical procedure, it kills patients half the time.

Another example of a fungus whose resistance worries the hospital world is Aspergillus fumigatus, a mold ubiquitous in the environment and which constitutes a danger for people with weakened immune systems. “In the Netherlands, where tulip fields are watered with antifungals, 10% of patients who arrive at hospital with an Aspergillus infection have resistant strains.” To treat them, doctors must use a last-line antifungal that is particularly toxic for patients. Once again, the extraordinary capacity of microorganisms to adapt and environmental degradation are increasing health threats.
https://lejournal.cnrs.fr/articles/pand ... nel-retour
(Bonus) Proof that it resists, “they” see it and say it: https://www.arvalis.fr/sites/default/fi ... 555696.pdf
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