The century-old mystery. How to live longer?

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Christophe
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by Christophe » 25/04/14, 10:46

In English:

Mutations Found In 115 Year Old Woman's Blood Could Help Unlock Secrets Of Aging

http://www.iflscience.com/health-and-me ... rets-aging

Hendrikje van Andel-Schipper died at the ripe old age of 115 in 2005, making her one of the longest lived humans on record. For a woman her age she was also in considerably good health until shortly before she passed away. She was also kind enough to donate her body to science and scientists have been eager to find out more about her, which may help to increase our understanding of aging. In particular, researchers based at the VU University Medical Center in Amsterdam were keen to know more about the accumulation of mutations in somatic cells as we age.

In the study, which has been published in the journal Genome Research, the team used deep whole-genome sequencing and found 450 somatic mutations within her healthy white blood cells. Furthermore, these mutations were enriched in noncoding regions that are not evolutionarily conserved and appeared to be harmless passenger mutations, unlike those associated with disease.

(...)
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by Christophe » 15/09/15, 13:31

http://www.levif.be/actualite/sante/gar ... 18035.html

Keeping an eternally young brain is possible!

Good news ! Contrary to popular belief, the brain makes neurons at any age. Provided you stimulate him, continue to learn and be curious. In short, the solution is in perpetual wonder.
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by Obamot » 15/09/15, 14:47

First thank you Christophe.

Then fully agree, and of course the motivation to walk there, I think you will be in phase to say that it is not easy, especially when you have a disability (and many who are concerned with age are in this case. But young people too.)

At the moment I am trying to do without sugar, I am xylitol, one of the rare molecules which causes only a modest insulonemia (therefore which does not exhaust the body ...) subject of which it will probably have to talk again and cross-check with other opinions ...

RTDC.
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by Christophe » 15/09/15, 15:13

Yes ... but in the spiral of depression it is precisely the motivation that no longer exists !!

From experience with my own personal brain (not yet tested that of others .... lol :D ) I particularly agree with these 3 passages from the article:

(...) People who are stimulated, and permanently in well-being, remain mentally young throughout their lives. Conversely, individuals who enter the routine very early, who have no surprises and have no motivation in life, lose the plasticity of their brain. The brain of a depressed person is frozen. No young neuron has (not ... to delete typing error) been found in suicides of chronically depressed for years. There is therefore a direct correlation between the number of contacts, stimuli and the number of neurons. People who have an extraordinary ability to adapt to the constantly changing world are those who show a greater faculty of neuroplasticity. (...)

What are the conditions for producing new neurons?

New stimuli, pleasure, curiosity and wonder. That said, not all pleasures have the same degree of benefit. When you read a book, your imagination gets carried away and you engage 85% of your mental activity. When watching a film, while remaining passive, only 15% of mental activity is in action. Poor brain in this case ...

(...)

What factors are harmful to the brain?

Chronic stress, depression, physical inactivity and isolation. A person who finds himself retired at 65, without a couple or family life, who sinks into the routine, who does not have a very rich sensory and emotional life and whose brain is no longer properly stimulated, is condemned. His immune system will collapse.

(...)
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Re: The mystery of the centenarians. How to live older?




by Christophe » 12/07/16, 12:59

Unravel the secrets of longevity in Japan: http://www.pourlascience.fr/ewb_pages/a ... -37280.php
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Re: The mystery of the centenarians. How to live older?




by Christophe » 14/07/16, 06:41

An interesting article about Nobel 2009: http://www.slate.fr/story/11207/nobel-2 ... -genetique

The three winners deciphered the main molecular bases of life.

The 2009 Nobel Prize in Medicine was awarded on Monday October 5 to the Americans Elizabeth Blackburn, Carol Greider and Jack Szostak (1). It rewards innovative, promising as well as disturbing and problematic work concerning life expectancy.

Officially the three researchers are distinguished "for having solved a major problem in biology: how chromosomes can be completely copied during cell division and how they are protected from degradation". Officially still the Karolinska Institute which awards the prestigious prize adds: “The Nobel laureates have shown that the solution is to be found at the ends of the chromosomes: telomeres; and in the enzyme that forms them: telomerase ”.

The "telomeres", therefore; and "telomerase". Please note: these two terms should not trigger antibodies against the rest of this text. Quite the contrary: they are at the crossroads of modern biology and eternal myths; they tell us - and the Nobel laureates it - that the molecular reading of the living brings us closer to the coping of the fountain of youth.

(...)
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Re: The mystery of the centenarians. How to live older?




by Christophe » 07/03/18, 18:09

The new trend of the moment of youth research ... the transfusion of a young organism into an older organism!

It works on mice but without knowing why exactly:



Hey bin that's enough to solve youth unemployment: sell your blood !!! : Cheesy:
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by Christophe » 07/03/18, 18:15

Christophe wrote: (...)
(...) People who are stimulated, and permanently in well-being, remain mentally young throughout their lives. Conversely, individuals who enter the routine very early, who have no surprises and have no motivation in life, lose the plasticity of their brain. The brain of a depressed person is frozen. No young neuron has (not ... to delete typing error) been found in suicides of chronically depressed for years. There is therefore a direct correlation between the number of contacts, stimuli and the number of neurons. People who have an extraordinary ability to adapt to the constantly changing world are those who show a greater faculty of neuroplasticity. (...)

What are the conditions for producing new neurons?

New stimuli, pleasure, curiosity and wonder. That said, not all pleasures have the same degree of benefit. When you read a book, your imagination gets carried away and you engage 85% of your mental activity. When watching a film, while remaining passive, only 15% of mental activity is in action. Poor brain in this case ...

(...)

What factors are harmful to the brain?

Chronic stress, depression, physical inactivity and isolation. A person who finds himself retired at 65, without a couple or family life, who sinks into the routine, who does not have a very rich sensory and emotional life and whose brain is no longer properly stimulated, is condemned. His immune system will collapse.

(...)


I still agree with this as much !!! And this explains well the decline in IQ and the increase in depression!
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Re: The mystery of the centenarians. How to live older?




by Janic » 08/03/18, 08:21

Hello
it is not enough to have active neurons when the rest of the body continues to degrade with age. A hundred-year-old bedridden is not the ideal to achieve either, and yet this is what tends to happen more and more in our societies (not centenarians but bedridden! : Cry: )
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Re: The mystery of the centenarians. How to live older?




by Leo Maximus » 08/03/18, 10:45

Christophe wrote:The new trend of the moment of youth research ... the transfusion of a young organism into an older organism!

This is the theme of the 1973 film "Shock Treatment" with Alain Delon and Annie Girardot. In a thalassotherapy center, the blood of Portuguese migrants is used for the youth cures of the elites.

https://fr.wikipedia.org/wiki/Traitemen ... film,_1973)
or: https://en.wikipedia.org/wiki/Shock_Tre ... (1973_film)

Very rarely rebroadcast on TV ...

Blood sells. It's called the "blood market": https://www.google.fr/search?client=fir ... SNlA5UAVUQ.
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