Covid and Didier Raoult (supporter of hydroxychloroquine): analyzes on the pandemic

[Christophe]

For my part, I continue to promote the use of duck confit, the results of which in prophylaxis in the department of Gers have been and remain remarkable.

I didn't know that there were still people living in the Gers

[Adrien (ex-nico239)]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

The observation by Lammers et al. (Lammers et al.) That early treatment with HCQ after low-dose admission (2400 mg total) is associated with a lower risk of ICU admission coincides with large observational studies showing a higher rate of lower mortality in patients exposed to HCQ treatment compared to no treatment or other treatment. It should be noted that in all of these studies and unlike the RECOVERY trial, low doses of HCQ (<2,5 gr. In total) were used, often shortly after admission (Arshad et al., 2020
, Ayerbe et al., 2020
, Catteau et al., 2020
; COVID-19 RISK and Treatments (CORIST) Collaboration 2020). Another recent large cohort study of patients on low dose HCQ for inflammatory disorders reported an association between chronic HCQ use and reduced mortality following SARS-CoV-2 infection (Gentry et al. 2020
).
As the results of Lammers et al point out, the timing of HCQ treatment (administration within the day after admission) could explain the differences between the different studies. In the RECOVERY trial, the median time from symptom onset to randomization was 9 days and a substantial proportion of patients (16,7%) were already on mechanical ventilation at randomization (The RECOVERY Collaborative Group 2020
).
HCQ has been used as an anti-inflammatory for decades as a treatment for inflammatory disorders, and its impact on inflammatory responses is well documented. HCQ inhibits the production of the pro-inflammatory cytokines interleukin (IL) -6, TNF-α and IL-1-β by activated macrophages (Sperber et al., 1993
, Jang et al., 2006
), which are notoriously associated with the severity of COVID-19 (Webb et al.; Del Valle et al. 2020) as well as the production of chemotactic cytokines involved in the recruitment of pro-inflammatory cells in the lungs (Grassin- Delyle et al. 2020
).

[pedrodelavega]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

As the anti-viral effect of HCQ does not work on covid19, it would now rely on an anti-inflammatory effect?

[Adrien (ex-nico239)]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

As the anti-viral effect of HCQ does not work on covid19, it would now rely on an anti-inflammatory effect?

Well, they are the doctors

[Obamot]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

As the anti-viral effect of HCQ does not work on covid19, it would now rely on an anti-inflammatory effect?

Well, they are the doctors

disco very
Recovery

But no delivery

After 8 months of gestation, we still do not know with what the detractors of the rare affordable treatments that have allowed significant advances and cures expect to treat the sick?

... on the other hand the recurring denial of many studies which are published every week turns in a “very much” loop

[VetusLignum]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

As the anti-viral effect of HCQ does not work on covid19, it would now rely on an anti-inflammatory effect?

For weeks, you have been told that HCQ has an antiviral effect at the very beginning of infection, combined with AZI and / or zinc, and an anti-inflammatory (immunomodulatory) effect in the middle stage.

[Christophe]

Obamot, do not put an url tag on videos, this prevents their integration into the forum...

[Christophe]

The very interesting update by Dr Nicolas Dauby in the International Journal of Infectious Diseases on the use of hydroxychloroquine in the Discovery study


The unfinished story of hydroxychloroquine in COVID-19: the right anti-inflammatory dose at the right moment?

As the anti-viral effect of HCQ does not work on covid19, it would now rely on an anti-inflammatory effect?

For weeks, you have been told that HCQ has an antiviral effect at the very beginning of infection, combined with AZI and / or zinc, and an anti-inflammatory (immunomodulatory) effect in the middle stage.

Not weeks, months yes !!

[pedrodelavega]

For weeks, you have been told that HCQ has an antiviral effect at the very start of an infection, combined with AZI and / or zinc,

Yes I know. You say so. Well finally, there would be no anti-viral effect according to Nicolas Dauby. Raoult could be wrong. It is possible. He was very wrong on certain points.
For example: The Chinese who first applied for this molecule no longer recommend the HCQ / AZT association.

and an anti-inflammatory (immunomodulatory) effect in the intermediate stage.

This is not demonstrated in SOLIDARITY for example.

A given moment, given the mess it is, the economic cost, the political cost (there is not a ruler who is gaining in popularity at the moment), the competition between the states, etc ... etc ..., the fact that this case would simply boil down to "there is an effective treatment but it is not used because it brings nothing" seems highly improbable ....
(We use dexa, it doesn't cost anything. Remdesivir ineffective in SOLIDARITY, etc.)

What science is saying now:
pollution-prevention-health / the-advances-in-the-fight-against-coronavis-t16395-520.html # p414616

[VetusLignum]

For weeks, you have been told that HCQ has an antiviral effect at the very start of an infection, combined with AZI and / or zinc,

Yes I know. You say so. Well finally, there would be no anti-viral effect according to Nicolas Dauby. Raoult could be wrong. It is possible. He was very wrong on certain points.
For example: The Chinese who first applied for this molecule no longer recommend the HCQ / AZT association.

and an anti-inflammatory (immunomodulatory) effect in the intermediate stage.

This is not demonstrated in SOLIDARITY for example.

A given moment, given the mess it is, the economic cost, the political cost (there is not a ruler who is gaining in popularity at the moment), the competition between the states, etc ... etc ..., the fact that this case would simply boil down to "there is an effective treatment but it is not used because it brings nothing" seems highly improbable ....
(We use dexa, it doesn't cost anything. Remdesivir ineffective in SOLIDARITY, etc.)

What science is saying now:
pollution-prevention-health / the-advances-in-the-fight-against-coronavis-t16395-520.html # p414616

Or how to try again to reset the counters to zero, by putting back on the table everything that has already been refuted before.
Personally, I'm not going to waste any more time with you.