Health and prevention. Pollution, causes and effects of environmental hazardsIs Germany (already) using Plaquenil (Chloroquine) against Covid-19?

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Adrien (ex-nico239)
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby Adrien (ex-nico239) » 03/05/20, 00:17

Well, it's not so dangerous ...

The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection
https://www.ahajournals.org/doi/10.1161 ... 120.008662


Background - The new SARs-CoV-2 coronavirus is responsible for the global COVID-19 pandemic. Small studies have shown a potential benefit of chloroquine / hydroxychloroquine ± azithromycin for the treatment of COVID-19. Using these drugs alone or in combination may cause a prolongation of the QT interval, possibly increasing the risk of torsade de pointes (TdP) and sudden cardiac death.

Methods - Inpatients treated with chloroquine / hydroxychloroquine ± azithromycin from March 1 to 23 in three hospitals in the Northwell health system were included in this prospective observational study. Serial QT interval assessments were performed. The main result was a prolongation of the resulting QT interval Secondary results included a prolongation of the QT interval, the need to stop one of the drugs prematurely due to a prolongation of the QT interval and a arrhythmogenic death.

Results - Two hundred and one patients were treated for COVID-19 with chloroquine / hydroxychloroquine. Ten patients (5,0%) received chloroquine, 191 (95,0%) received hydroxychloroquine and 119 (59,2%) also received azithromycin. The main outcome of the TdP was not The basic QTc intervals did not differ between the patients treated with chloroquine / hydroxychloroquine (monotherapy group) and those treated with the combined group (chloroquine / hydroxychloroquine and azithromycin) (440,6 ± 24,9 , 439,9 ms vs 24,7 ± 0,834 ms, p = 470,4) The maximum QTc during treatment was significantly longer in the combined group vs the monotherapy group (45,0 ± 453,3 ms vs 37,0 ± 0,004 ms, p = 3,5). Seven patients (XNUMX%) had to discontinue these drugs due to QTc prolongation. No arrhythmogenic deaths were reported.

Conclusions - In the largest cohort of patients treated with COVID-19 to date treated with chloroquine / hydroxychloroquine {plus minus} azithromycin, no cases of TdP or arrhythmogenic death have been reported. Although the use of these drugs has resulted in prolongation of the QT interval, clinicians have rarely had to stop further investigation of the need for QT interval monitoring is necessary before final recommendations can be made.
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Adrien (ex-nico239)
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby Adrien (ex-nico239) » 03/05/20, 00:22

The basics of the study appear to be correct and similar to the IHU protocol.
The objectives of the method are similar to those which we could discuss here ... try not to go through the hosto-intensive-réa box

I let you read the FAQ .... very interesting
https://depts.washington.edu/covid19trx/faqs/

Help find an effective treatment for COVID-19
https://depts.washington.edu/covid19trx/

This study will examine whether taking hydroxychloroquine (HCQ) or HCQ plus azithromycin is beneficial for non-hospitalized people with SARS-CoV-2 infection compared to placebo. We are concerned with whether these drugs will help reduce lung infection in people recently infected with COVID-19 and keep them from going to hospital.

COVID-19 Trial Explores Effectiveness of Hydroxychloroquine With and Without Azithromycin
https://www.technologynetworks.com/drug ... cin-333935

The University of Washington School of Medicine study is looking for people who have tested positive for COVID-19, but who are not sick enough to be hospitalized.

Registration is for two cohorts - high risk and low risk. High-risk outpatients are those over the age of 60 or with underlying risk factors, such as diabetes, hypertension, obesity, or lung problems.

The low-risk cohort consists of outpatients aged 18 to 59 years without any of these conditions. The trial will enroll 630 patients at sites across the country, including the University of Washington.

Other sites are planned in Boston, New Orleans, New York, Syracuse and Chicago.



Researchers enrolling COVID-19 patients for treatment trial (Study led by Christine Johnston / ICRC)
https://globalhealth.washington.edu/new ... ent-trial#
The trial volunteers are enrolled in three arms: hydroxychloroquine, hydroxychloroquine with the antibiotic azithromycin or a placebo.


The $ 5,8 million trial is funded by the COVID-19 therapeutic accelerator, an initiative launched by the Bill & Melinda Gates Foundation, Wellcome and Mastercard, with funding from a range of public and philanthropic donors. The accelerator was launched to accelerate the response to the COVID-19 pandemic by funding the identification, evaluation, development and intensification of treatments.


Hydroxychloroquine is an antiviral medication used since the early 50s. It is used to prevent malaria and to treat autoimmune diseases such as rheumatoid arthritis and lupus. The drug is believed to work by preventing the virus from entering the cell. Azithromycin is used to treat a wide variety of bacterial infections. It has some activity against many viruses in the laboratory, but it has not been shown to have antiviral activity in humans.

"This is not the kind of evidence the public needs at all," he said of the small studies. "This rigorous trial will quickly provide the answer if hydroxychloroquine with or without azithromycin is effective and safe, or if we need to switch to other potential therapies."

For 10 days, people under medication will receive 400 mg of hydroxychloroquine twice a day on the first day and 200 mg twice a day for the next nine days. A 500 mg dose of azithromycin will be administered on the first day of the study, followed by 250 mg once daily for four additional days.

The results of the trial are expected by July. The results will determine if a treatment looks promising enough for larger clinical trials and if the drugs are safe.
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby izentrop » 03/05/20, 10:00

Not sure Bill had the right intuition this time ...
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby pedrodelavega » 03/05/20, 12:32

GuyGadebois wrote:
pedrodelavega wrote:Furthermore, if we go this way, the Marseille IHU has links of interest with Sanofi which produces Plaquenil (hydroxychloroquine).
This molecule has fallen into the public domain ... : roll:
In France, only Sanofi produces it.
https://rmc.bfmtv.com/emission/la-coler ... 92696.html
https://www.mediterranee-infection.com/ ... partenaire

"Links", if you search, you will find them everywhere

GuyGadebois wrote:Then, when you don't want to see the obvious links between these labs and the "new study", you might as well go blind ...
There may be links. Is there addiction / cheating so far? In your 1st article, it is only mentioned an external collaboration with Nevan Krogan (is it within the framework of this study?). In the following, no link mentioned.
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby GuyGadebois » 03/05/20, 12:43

pedrodelavega wrote:
GuyGadebois wrote:
pedrodelavega wrote:Furthermore, if we go this way, the Marseille IHU has links of interest with Sanofi which produces Plaquenil (hydroxychloroquine).
This molecule has fallen into the public domain ... : roll:
In France, only Sanofi produces it. <<< So what? Given the price per tonne, Sanofi will bribe Raoult to promote it (So there is collusion)?

GuyGadebois wrote:Then, when you don't want to see the obvious links between these labs and the "new study", you might as well go blind ...
There may be links. Is there addiction / cheating so far? In your 1st article, it is only mentioned an external collaboration with Nevan Krogan (is it within the framework of this study?).<<< "External collaboration", well let's see ... : roll: In the following, no link mentioned.<<< The link is the molecule used, apart from usual use. Why did you choose it from thousands? Either you are naive, or in bad faith.

Personally I have NO confidence in these people. Neither in the labs that think only of profit, nor in those who take their cash to chew their work.
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby VetusLignum » 03/05/20, 13:33

Julienmos wrote:https://www.ladepeche.fr/2020/05/01/coronavirus-une-nouvelle-etude-identifie-plusieurs-molecules-prometteuses-et-ecarte-lhydroxychloroquine,8870144.php

The study can be found here: https://www.nature.com/articles/s41586- ... erence.pdf

This study finds the in vitro effect of hydroxychloroquine on covid-19 (effect which had already been demonstrated by a Chinese study).
It suggests a possible explanation for the cardiac effects (already widely known) of hydroxichloroquine.

I do say : "It evokes a possible explanationn "; extract:"Indeed, the lack of selectivity of chloroquine and hydroxychloroquine versus hERG and other off-targets may be related to the cardiac adverse drug reactions that have limited their use". The article, which says"Beware of hydroxychloroquine"then"This new study also demonstrates the origin of the cardiac adverse effects of hydroxychloroquine", is therefore false.

Note here that we are at the anti-viral stage; that is, at the first stage of infection. hydroxychloroquine is available, works, and its side effects are known. So this is the treatment to use now. This does not mean that in a few months, we will not have found better. The fact that two other well-known molecules (clemastine and cloperastine) have an in vitro effect is also one of the promising lessons from this study.
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby thibr » 03/05/20, 13:42

in vitro bleach and very effective as said ... Trump : Mrgreen:
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby VetusLignum » 03/05/20, 13:43

pedrodelavega wrote:
GuyGadebois wrote:
pedrodelavega wrote:Furthermore, if we go this way, the Marseille IHU has links of interest with Sanofi which produces Plaquenil (hydroxychloroquine).
This molecule has fallen into the public domain ... : roll:
In France, only Sanofi produces it.
https://rmc.bfmtv.com/emission/la-coler ... 92696.html
https://www.mediterranee-infection.com/ ... partenaire

"Links", if you search, you will find them everywhere

GuyGadebois wrote:Then, when you don't want to see the obvious links between these labs and the "new study", you might as well go blind ...
There may be links. Is there addiction / cheating so far? In your 1st article, it is only mentioned an external collaboration with Nevan Krogan (is it within the framework of this study?). In the following, no link mentioned.


Laboratories have no interest in hydroxychloroquine; they often link it.
https://www.sanofi.com/en/media-room/pr ... 0-07-55-20
https://www.novartis.com/news/media-rel ... c-response
https://www.fiercepharma.com/pharma/new ... tablets-to
https://www.hhs.gov/about/news/2020/03/ ... ients.html
https://www.epmmagazine.com/news/accord ... o-million/
https://timesofindia.indiatimes.com/bus ... 039058.cms
https://www.reuters.com/article/us-heal ... SKBN21637E
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby pedrodelavega » 03/05/20, 18:36

VetusLignum wrote:Laboratories have no interest in hydroxychloroquine; they often link it.

For those who are convinced by Raoult: Hydroxychloroquine is effective but we do not want to use it because the molecule is not expensive enough and in the public domain and / or we do not want to give reason to Raoult ...
But at the same time the labs have increased their production and are distributing it all over the place, look for the error ..... : Shock:

I prefer to remain cautious and follow the assumption that for the moment, the effectiveness of its remedy is not proven. It is being tested like a plethora of other remedies. As soon as a remedy proves its effectiveness, the scientific consensus will be broad and rapid because all, at the international level, are affected by this epidemic, doctors, researchers, laboratory workers, government officials as well as their parents, children, relatives.
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Re: Is Germany (already) using Plaquenil (Chloroquine) against Covid-19?

Unread Messageby sicetaitsimple » 03/05/20, 19:03

pedrodelavega wrote: As soon as a remedy proves its effectiveness ......


I have no knowledge in medicine, but I have the impression that we could go towards remedies, according to the age of the patient, his medical history, the severity of his symptoms, etc.
This makes these pro / anti Pr.Raoult controversies a bit sterile / ridiculous by people like me who know absolutely nothing about medicine, but who are however able to compare figures which are absolutely not comparable.
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