Christophe wrote:GuyGadebois wrote:http://translate.google.com/translate?hl=fr&sl=auto&tl=fr&u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41422-020-0282-0
Well, isn't that a confirmation by a review committee?
if beast and his infectiologist can go to bed !!
For the lazy, extract from the article:
Chloroquine, a widely used anti-malarial and autoimmune drug, has recently been reported as a potential broad-spectrum antiviral drug. 8, 9 Chloroquine is known to block viral infection by increasing the endosomal pH required for virus / cell fusion, as well as by interfering with the glycosylation of cellular SARS-CoV receptors. 10 Our test at the time of addition demonstrated that chloroquine functioned both at the entry and at the post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). In addition to its antiviral activity, chloroquine has an immunomodulatory activity, which can synergistically strengthen its antiviral effect in vivo. Chloroquine is widely distributed throughout the body, including the lungs, after oral administration. The EC 90 value of chloroquine compared to 2019-nCoV in Vero E6 cells was 6,90 μM, which may be clinically feasible, as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg of administration . 11 Chloroquine is a cheap and safe drug that has been used for over 70 years and, therefore, is potentially clinically applicable against 2019-nCoV.
Our results show that remdesivir and chloroquine are very effective in controlling 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a history of safety and have been shown to be effective against a variety of diseases, we suggest that they should be evaluated in human patients suffering from the new coronavirus disease.
