Brain, heart, blood vessels ... in 20 to 30% of cases
From images of blurred chest scans and panting patients hooked up to ventilators, we have been conditioned to view Covid-19 as a respiratory illness. But it's not just a question of the lungs.
Even in the early days of the pandemic, doctors discovered that a new coronavirus infection could devastate other parts of the body, including the brain, blood vessels and heart.
Data from the initial outbreaks in China, New York and Washington state suggest that 20-30% of patients hospitalized with Covid-19 showed signs of heart damage.
The fact that these patients tended to become sicker and die more often than patients without cardiac complications did not raise the immediate alarm.
They were, after all, people with severe cases of Covid-19 - severe enough to end up in hospital. Most people who contract the virus have a range of less severe symptoms.
Up to one in three people don't feel sick. But now, evidence is emerging that the virus can cause heart damage even in people who have had mild symptoms or no symptoms at all, especially if those people exercise while they are infected.
Last month, when the Big Ten and Pac-12 College Conference League commissioners announced they would be postponing the fall 2020 sports season, one of the main factors they cited were concerns about it. called myocarditis.
This is the cardiologist's talk for what happens when the muscle walls of the heart become inflamed, weakening the organ and making it harder to pump blood. It is not a newly discovered disease, and it happens quite rarely, but when it does, it is most often triggered by an infection. Viruses, bacteria, even invading amoebae, yeasts and worms have been shown to be the cause.
What they have in common is that they put the body's immune system into attack mode, resulting in inflammation. If a person rests while they are sick and recovering, most of the time the inflammation goes away and the heart muscle heals on its own. But strenuous activity while the heart is weakened can cause leg swelling, dizziness, shortness of breath, and in severe cases, irregular heartbeat, cardiac arrest, and sudden death.
These more extreme results are seen most often in competitive athletes. This is why cardiologists have urged caution about the return of sport in the middle of the pandemic. Former Florida state basketball player Michael Ojo died last month of apparent heart complications while playing in a professional league in Serbia, shortly after the 27-year-old recovered from Covid- 19.
To prevent the pandemic from leading to equally tragic heart injuries in student athletes, doctors at Ohio State University have developed a new protocol, said Saurabh Rajpal, cardiologist and assistant professor of internal medicine at OSU. The protocol requires any player diagnosed with Covid-19 to undergo a physical examination, blood test, EKG, and MRI - an expensive and infrequently used imaging technology - before resuming play.
Between June and August, 26 men and women from the school's football, soccer, lacrosse, basketball and track teams showed up for screening after recovering from Covid-19. MRI scans revealed inflammation of the heart muscle - a sign of myocarditis - in four of them. Of these, two had never shown symptoms of Covid-19. The case series was reported on Friday in the journal JAMA Cardiology.
Because the athletes' hearts were not imaged prior to their Covid-19 infections, and because they were not matched with witnesses - similar people who did not contract the virus - it is impossible to say with certainty if the virus caused the damage observed. . But Rajpal, one of the study's co-authors, says other viral infections cause myocarditis and SARS-CoV-2 is no different. “It's important for people to know that Covid-19 can affect the heart,” he says.
And these problems don't just affect athletes. A larger observational study conducted in Germany earlier this summer followed 100 non-athletic Covid-19 patients and found persistent heart inflammation and other heart abnormalities in 78 of them.
According to Eric Topol, a U.S.-based cardiologist who corresponded with the study authors, 12 of those people had no symptoms of Covid-19. And although the study was later corrected for statistical errors, its authors confirmed that the main conclusions still hold true: even a mild cure of Covid-19 could harm the heart.
Exactly how much and how often, well, no one knows yet, says Topol, who heads the Scripps Research Translational Institute in La Jolla, Calif. “It's an unexplored frontier,” he says. The evidence is still mostly anecdotal. He would like to see governments and other research funders set aside money to more systematically study large cohorts of people to see what happens to them after contracting Covid-19.
But so far that doesn't seem like a high priority. This may be because many other viruses can also cause myocarditis, Topol speculates. But the difference here - and what should prompt more urgent study, he believes - is that most viruses don't infect tens of millions of people within six months.
“In the United States today, it is estimated that more than 50 million people have been infected with this virus,” he says. (There have been 6,5 million confirmed cases, but due to the testing infrastructure in the United States, experts estimate the actual number to be closer to 10 times that.)
Even though only 1% of Americans have some kind of heart problem, that's still 500000 people. . “That's what people are losing here,” Topol says. “It doesn't take a lot of impact when this virus has passed through so many people to be a huge burden. That's why we need to put our arms around this and figure it out ASAP. "
Scientists still do not know whether the inflammation seen in patients with Covid-19 is a collateral injury to the body's immune response or from the virus directly infecting heart tissue. Heart muscle cells express ACE2, the molecular gate that the coronavirus uses to invade new hosts.
And autopsy studies have found the virus in the hearts of patients who died from Covid-19. (Although, notably, not the types of immune cells associated with an inflammatory response.) Earlier this month, scientists at the San Francisco-based Gladstone Institutes found that the virus, when added to human heart cells in a Petri dish, shredded the long muscle fibers that make the heart beat. Bruce Conklin, one of the study's co-authors, told STAThe “carnage” was unlike anything seen with other illnesses. But more research is needed to better understand whether this is representative of what is actually going on inside the bodies of people infected with Covid-19.
The need is particularly critical because so many people infected with the coronavirus do not know it. And they may unintentionally do things - like exercise - that could damage their heart during or immediately after their infection. Amateur athletes in particular, such as marathon runners, ultrarunners, triathletes and others who cover a lot of miles but do not have access to regular heart tests, might not be aware enough of the risks to make judgments about the risk. safety of their training programs.
That is why Rajpal suggests paying special attention to your body if you are going out for a difficult run, bike ride, or other athletic activity, especially if you have any suspicion of illness. “If you experience any suspicious symptoms - chest pain, shortness of breath, or heart palpitations - contact your doctor,” he says. And if you've tested positive for Covid-19, he says, you should take a few weeks off before gradually returning to the training level you were at before.
At OSU, athletes who showed signs of myocarditis on their MRI scans were put on mandatory three-month rest. At the end of that, they'll be reanalyzed to make sure the inflammation has subsided, and only then, Rajpal says, will they be allowed to play.