Advances in the fight against the coronavirus

[Christophe]

Then the barrier gestures that are also ... important in the fight against coconut ...

[Christophe]

Melatonin, much more effective than dexamethasone on intubated patients.
https://www.medrxiv.org/content/10.1101 ... 1.full.pdf

Very good study which compares many molecules! Thanks for posting it!

Well, I didn't understand anything about the tables or the figures but I trust them on the conclusions!

Results

Among the 189,987 patients, we identified 948 intubation periods across 791 patients who were diagnosed with COVID-19 or infected with SARS-CoV2 and 3,497 intubation periods across 2,981 patients who were not. Melatonin exposure after intubation was statistically associated with a positive outcome in COVID-19 (demographics and comorbidities adjusted HR: 0.131, 95% CI: 7.76E-02 - 0.223, p-value = 8.19E-14) and non-COVID-19 (demographics and comorbidities adjusted HR: 0.278, 95% CI: 0.142 - 0.542 1.72, p-value=04E-19) intubated patients. Additionally, melatonin exposure after intubation was statically associated with a positive outcome in COVID-0.127 patients (demographics and comorbidities adjusted HR: 95, 6.01% CI: 02E-0.269 - 7.15, p-value = 08E-XNUMX).

conclusions

Melatonin exposure after intubation is significantly associated with a positive outcome in COVID-19 and non-COVID-19 patients. Additionally, melatonin exposure after intubation is significantly associated with a positive outcome in COVID-19 patients requiring mechanical ventilation. While our models account for many covariates, including clinical history and demographics, it is impossible to rule out confounding or collider biases within our population. Further study into the possible mechanism of this observation is warranted.

[Adrien (ex-nico239)]

Melatonin - vitamin D are they not cousins?

[Christophe]

If you think of the tanning molecule melanin (as I thought about it) it's no ...

Otherwise I don't know ...

[Adrien (ex-nico239)]

You're right in fact melatonin is the sleep hormone ...
Okay, she's my girlfriend so

[Obamot]

If you think of the tanning molecule melanin (as I thought about it) it's no ...

Otherwise I don't know ...

HUG medics take care of their sleep, they say, which is required for good immunity.

Carry out randomized studies of molecules against covid with supplements: sometimes zinc, sometimes vitamin D, sometimes melatonin is good, but what matters is to have all of these nutrients available in the diet every day. days and at the required dose. And avoiding the overdose of poisons and addictive substances is not bad either, as disruptors of all this mess ...

Do you have to wait until you get sick to do this !?

[Adrien (ex-nico239)]

Publication of the results of the SOLIDARITY clinical trial (WHO):

https://www.medrxiv.org/content/10.1101 ... 20209817v1

capture.jpg

Unfortunately, none of the molecules tested showed efficacy against covid-19.
Including remdesivir (Gilead not happy but we are not doing international collaborative trials to please the labs https://www.gilead.com/-/media/gilead-c ... .pdf?la=en )

Gilead doesn't give a damn.

It is only the dough that interested him and everyone knows it.
He managed to sell his stuff around the world that was the only thing that mattered.
All intermediaries and lobbyists will be paid handsomely: bingo

And here is 63 million € thrown out the window ...

But who do not return the door it seems since we are still trying to refurbish the thing ...

ekw1xgrwkaiv8xg.jpg (143.65 KiB) Viewed 815 times

To your good heart, ladies and gentlemen, you will take a teaspoon of remdesivir ....

What a motherfucker world

[Adrien (ex-nico239)]

And you will take a small dose of rivotril ...

After spring, the start of the school year will be again in the EPHADs

prescription rivotril.jpg (144.33 KiB) Viewed 802 times

[izentrop]

Good summary, thank you Izy
You could just have added that wearing a mask seems to decrease the severity of cases as well ... I don't know if we already have double "blind" studies on it ... they would not be very correct ethically but there are enough of "real" cases to be able to decide I think ...

For the reduction of severe cases, the most logical explanation in the end:

If there are fewer serious cases, it is because it is especially among 15-44 year olds that contamination increases. A population unlikely to develop severe forms of the coronavirus. The risk is that seniors will end up suffering. Another explanation: better patient care. Today, there is still no specific treatment, but we know better how to detect and treat the most serious cases. https://www.francetvinfo.fr/sante/malad ... 84127.html

[Adrien (ex-nico239)]

Good summary, thank you Izy
You could just have added that wearing a mask seems to decrease the severity of cases as well ... I don't know if we already have double "blind" studies on it ... they would not be very correct ethically but there are enough of "real" cases to be able to decide I think ...

For the reduction of severe cases, the most logical explanation in the end:

If there are fewer serious cases, it is because it is especially among 15-44 year olds that contamination increases. A population unlikely to develop severe forms of the coronavirus. The risk is that seniors will end up suffering. Another explanation: better patient care. Today, there is still no specific treatment, but we know better how to detect and treat the most serious cases. https://www.francetvinfo.fr/sante/malad ... 84127.html

Why re-define if we have fewer severe cases?